To create a PICOTS that contains all essential elements To know that extra elements in PICO are timing and setting To judge to which category a review belongs (but only for clear examples) and to evaluate whether a title has an adequate format What the differences between types of prognosis studies are. What prognosis is, why we prognosticate, what the difference is with diagnosis and where SRs of prognosis studies can help Given that treatment targeting gene mutations had a significant impact on prognosis, we primarily chose the era in which EGFR-TKI was widely used in clinical practice.What you can expect to learn (learning outcomes) Finally, as chemotherapy progresses, the postoperative treatment type has evolved. Third, the case registry period was 11 years, which was excessively long. Thus, our estimated HR for EGFR mutation might not be fully explained by these biases and might partly reflect the true association. However, these non-differential misclassifications could distort our results only toward the null. Therefore, pathological and clinical staging are mixed, and staging migration may exist. Second, because this was a collaborative multicenter study, there was some measurement misclassification in the surgical procedure depending on the facility. Undertaking prospective studies is challenging because it is difficult to register cases where PD is not suspected before surgery. Ī limitation of this study is that it was conducted retrospectively. On the other hand, the 5-year OS of patients with EGFR wild-type was 27.8% in the resected group ( n = 24) and 25.1% in the exploratory thoracotomy group ( n = 18). The 5-year OS of the resected group was 86.4%, compared with 44.8% in the exploratory thoracotomy group, and patients with primary lung tumor resection showed a significantly better 5-year OS than those with exploratory thoracotomy ( p < 0.001). The median duration of observation was 48.1 months. EGFR-TKI was administered to 18 patients in the resected group and 15 patients in the exploratory thoracotomy group. When comparing the exploratory thoracotomy group with the primary lung tumor-resected group, the number of patients who received additional distilled water perfusion therapy intraoperatively was significantly higher in the primary tumor resection group, and the number of D2-positive patients was significantly higher in the exploratory thoracotomy group. The clinicopathological characteristics of patients with EGFR mutation in the primary lung tumor-resected group ( n = 20) and exploratory thoracotomy group ( n = 21) are shown in electronic supplementary Table 1. We performed a survival analysis by limiting the analysis to 41 patients with EGFR mutation. OS was defined as the day of surgery to the day of death or the last follow-up day. Since thoracic lavage cytology-positive cases were not reflected in the clinical stage, they were excluded. The medical records were reviewed and analyzed retrospectively, and the degree of PD was classified as follows: D0, MPE without disseminated nodules D1, 1–5 disseminated nodules D2, > 5 disseminated nodules. The patients’ clinicopathological factors are shown in Table 1. We extracted 114 Japanese patients (1.2%) of stage IVA patients with NSCLC whose PD or MPE was found during or after surgery, from 9463 patients with NSCLC registered in the Okayama University Thoracic Surgery Study Group (OUTSSG) multicenter database of nine hospitals belonging to OUTSSG, from January 2005 to December 2015. Written informed consent from each patient was waived, and all methods in this study were in compliance with the relevant guidelines and regulations. 1804-040, 24 April 2018), and every joint research facility also obtained permission from each Ethics Commission. This study protocol was approved by the Ethics Committee of Okayama University Hospital (No.
0 Comments
Leave a Reply. |